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Faculty

Dr. Peter KvietysDr. Peter Kvietys
Professor of Physiology
College of Medicine
Alfaisal University
Riyadh, KSA

Email: pkvietys@alfaisal.edu
Tel: (+966 1) 215- 7673

 

Education:    
Post-Doc 1980 Dept. of Physiology, Univ. of South Alabama
Ph.D. 1979 Dept. of Physiology, Michigan State Univ.
M. Sc. 1975 Dept. of Physiology, Michigan State Univ.
B. Sc. 1972 Biology, Western Michigan University
     
Employment:  
Alfaisal University 2010  Professor, College of Medicine
London Health Sciences Centre 1997  Director, Vascular Biology
  1995 Scientist
Louisiana State University 1991 Professor, Dept. of Physiology
  1986  Assoc. Professor, Dept. of Physiology
Univ. of South Alabama 1984 Assoc. Professor, Dept. of Physiology
  1981 Assist. Professor, Dept. of Physiology
     

Research:

  • General interests: Basic mechanisms of the inflammatory response, inflammatory pathologies, microcirculation, vascular biology, neutrophil-endothelial interactions. Pathologies addressed to date include IBD & gastritis (gastrointestinal), ARDS (pulmonary), ischemia/reperfusion (heart), In general, pathologenesis is explored using in vivo (whole animal/organ) and in vitro (cell/molecular biology) approaches.

Editorial boards:

  • American Journal of Physiology, Gastrointestinal and Liver Section, (Assoc.Ed.)
  • Pathophysiology
  • Microcirculation
  • Journal of Critical Care
  • Journal of Clinical Biochemistry & Nutrition

Government consultant:

  • Canadian Institutes of Health Research (Canada)
  • National Institutes of Health (USA)
  • American Veterans Administration (USA)
  • Crohn’s and Colitis Foundation of Canada (Canada)
  • Heart and Stroke Foundation (Canada)
  • Potuguese Science and Technology Foundation (Portugal)

Research Conferences organized:

  • FASEB Research Conference “Physiology and Pathophysiology of the Splanchnic Circulation” (USA) – Vice Chairman & Chairman
  • Oxidative Stress Consortium (Canada) Organizing Committee

Publications:
Peer-reviewed papers ≈ 150 (see PubMed listing for details)

  • Madorin, W.S., T. Rui, N. Sugimoto, O. Handa, G. Cepinskas, and P.R. Kvietys. Cardiac myocytes activated by septic plasma promote neutrophil transendothelial migration: role of PAF and the chemokines, LIX and KC. Circ. Res. 94: 944-951, 2004
  • Rui, T., Q. Feng, M. Lei, T. Peng, J. Zhang, M. Xu, E.D. Abel, A. Xenocostas, G.
    Cepinskas, and P.R. Kvietys. Erythropoietin protects cardiac myocytes from the dysfunction and injury induced by simulated ischemia/reperfusion: role of nitric oxide. Cardiovasc. Res 65: 719 – 727, 2005
  • Handa, O., Naito, Y., Takagi, T., Shimozawa, M., Kokura, S., Yoshida, N., Matsui, H., Cepinskas, G., Kvietys, P.R., Yoshikawa, T. TNF-(alpha) – induced CINC-1 production by rat gastric epithelial cells: Role of ROS and NF (kappa) B. J Pharmacol Exp Ther. 309:670-676, 2004
  • Rui, T. and Kvietys, P.R. NFκB and AP-1 differentially contribute to the induction of Mn-SOD and eNOS during the adaptational response to oxidant stress. FASEB J. 19: 1908-10, 2005.
  • Dungey, A.A., A. Badwar, A. Bihari, PR Kvietys, KA Harris, TL Forbes, and RF Potter. Role of Hemeoxygenase in the protection afforded skeletal muscle during ischemic tolerance. Microcirculation 13: 71 – 79, 2006.
  • Yang, M., Wu, J., Martin, C. Kvietys, P.R., and Rui, T. Important role of p38 MAP kinase/NFκB signalling pathway in the sepsis-induced conversion of cardiomyocytes to a proinflammatory phenotype. Am. J. Physiol. Heart & Circulatory Physiol. 294: H994-H1001, 2008.
  • Sugimoto, N., Yoshida, N., Bharwani, S., Rui T., and Kvietys, P. Points of control exerted along the macrophage-endothelial cell-PMN axis by PECAM-1 in the innate immune response of acute colonic inflammation. J. Immunol. 181: 2145-54, 2008.
  • Wang, Z., M. Yang, T. Rui, S. Mehta, P.R. Kvietys. Alveolar macrophages from septic mice promote neutrophil migration via an endothelial c-Src kinase/NADPH oxidase pathway. (J. Immunol. 181: 8735-44, 2008.
  • Wu, J., M. Yang, C. M. Martin, P.R. Kvietys, and Rui, T. Activation of NADPH oxidase contributes to conversion of cardiac myocytes to a proinflammatory phenotype in sepsis. Free Radic Biol Med. 46: 1338-44, 2009.
  • Xu, H., J. Wu, M. Yang, J. Penninger, C. Martin, P.R. Kvietys, and T. Rui. The alarmin cytokine, HMGB1, is produced by viable cardiomyocytes and mediates the LPS-induced myocardial dysfunction via TLR4/PI3Kγ pathway. J. Immunol. 184: 1492-1498, 2010.
  • Kvietys, P.R. and D.N. Granger. Role of lymphatics in intestinal water transport. N.Y. Acad. Sciences. Suppl1:E29 – 43, 2010. (invited review).
  • Granger, D.N. and Kvietys. New insights into the role of reactive oxygen and nitrogen species in vascular disease. Free Radic. Biol. Med. (invited review, in preparation)

Graduate students and postdoctoral fellows ≈ 25
Books and other works 4
Chapters in Books 29
Invited presentations > 60

 

Previous funding:

  • NIH, AHA, Personal operating grants 1981 – 1994
  • CIHR, Personal operating grants 1995 – 2008
  • CIHR, Group grant (Director) 1997 – 2008

Current funding: applied for

 

Teaching:

  • Medical & Graduate level Gastrointestinal and Cardiovascular Physiology

 

 

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