Faculty

Dr. Bernhard Juurlink Dr. Bernhard Henricus Jozef Juurlink
Professor of Anatomy & Cell Biology
College of Medicine
Alfaisal University

Email: Jbernhard@alfaisal.edu
Tel : +(966-1) 215-7664 office

Education:
Post-Doc	1978	University of Saskatchewan, Canada, College of Medicine, Neuroscience
PhD	1975	McMaster University, Canada, Division of Medical Science, Teratology
M.Sc.	1971	Acadia University, Canada, College of Science, Developmental Biology
B.Sc.	1969	Acadia University, Canada, College of Science, Biology/Chemistry

Research Interests:

The role of oxidative stress and inflammation in diseases of aging (e.g., hypertension, type 2 diabetes, dementia) and following trauma, in particular brain & spinal cord injury as well as stroke.
Dietary and pharmacological approaches to decrease oxidative stress and associated problems, with special interest in dietary compounds that can increase the expression of anti-oxidant genes (i.e., phase 2 protein genes).
Identification and characterization of dietary phase 2 protein inducers.
Overcoming drug and radiation resistance in cancer cells.
Understanding the bases for cellular toxicity in nanomaterials.
Novel ways of imaging cells in vivo using synchrotron x-rays.
Novel mechanisms of x-ray-mediated cell damage.

Current projects:

Funded:

“Discovery and characterization of plant-derived phase 2 protein inducers”. B.H.J. Juurlink (PI), Jon Page and Jim Johnstone. Funding by a National Sciences & Engineering Research Council (NSERC) of Canada’s Collaborative Health Program grant. This project not only identifies new plant-derived phase 2 protein inducers but is also attempting to convert a crucifer weed into a functional food.
“Research and Community Alliance for Quality of Life in Long Term Care (The QOL Team)”. This is a team grant headed by Thomas Hadjastravropoulis that is examining interventions that lead to healthier life style in the elderly. Dr. Juurlink’s part in this, together with Susan Whiting, is to determine whether increased vitamin D3 intake and flax lignan intake decreases problems associated with oxidative stress and inflammation in elderly living in long-term care homes. Funded by the Saskatchewan Health Research Foundation (SHRF).
“The effects of Troglitazone on histone metabolism in multiple drug resistant breast cancer”. Troy A.A. Harkness (PI) and B.H.J. Juurlink. Funded by the Canadian Breast Cancer Foundation.

Active Research Projects with Minimal Funding:

Using gold nanoparticles to track brain cancer cell metastasis using synchrotron-generated x-rays.
Light production following X-ray interaction with tissue.
Understanding the bases of toxicity of carbon nanotubes and asbestos.

Research Grants Awarded:

KACST –Annual Research / Grants Program, Bernhard H.J. Juurlink (PI) and Ali A. Khraibi. “Phase 2 Protein Induction, Sirt1 and Gluconeogenesis”.
KACST –Annual Research / Grants Program, Ali A. Khraibi (PI), Wesam Kurdi, Bernhard H.J. Juurlink. “Renal and Cardiovascular Adaptations to Hypertensive Pregnancy”.

Publications: (since 2005 )
Refereed journal papers:

Schültke, E., R. Griebel and B.H.J. Juurlink. 2010. Quercetin attenuates inflammatory processes after spinal cord injury in an animal model. Spinal Cord in press
C. Hall, E. Sturm, E. Schültke, F. Arfelli, R-H Menk, A. Astolfo and B.H.J. Juurlink. 2010. Progress in cell marking for synchrotron x-ray computed tomography. In: Proceedings of the 6th Medical Applications of Synchrotron Research (MASR). American Institute of Physics, in press
Schültke, E., S. Fiedler, C. Nemoz, L. Ogieglo, M.E. Kelly, P. Crawford, F. Esteve, T. Brochard, M. Renier, H. Requard, G. LeDuc, B.H.J. Juurlink and K. Meguro. 2009. Synchrotron-based intra-venous K-edge digital subtraction angiography in a pig model: a feasibility study. European Journal of Radiology, in press
Adolphe, J.L., S.J. Whiting, B.H.J. Juurlink, L.U. Thorpe and J. Alcorn. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. British Journal of Nutrition, in press
Schültke, E., H. Kamencic, V. Skihar, R.W. Griebel and B.H.J. Juurlink. 2010. Quercetin in an animal model of spinal cord compression injury: Correlation of treatment duration with recovery of motor function. Spinal Cord 48: 112-117.
Marrif, H.I., A. N.A. Alwabel, A.E. Abdulhameed and B.H.J. Juurlink. 2010. Migraine headache: the astrocyte connection. American Journal of Scientific Research 8: 68-77.
Schültke, E, R.W. Griebel, B.H.J. Juurlink. 2010. Quercetin administration after spinal cord trauma changes S-100  levels. Canadian Journal of Neurological Sciences, 37 223-228.
Davies, G.F., A.R. Ross, T.G. Arnason, B.H.J. Juurlink, B.H.J. and T.A.A. Harkness, 2010. Troglitazone inhibits histone deacetylase activity in breast cancer cells. Cancer Letters 288: 236-250.
Schültke, E., V. Sadanand, M. Kelly, R. W. Griebel and B. H. J. Juurlink. 2009. Can admission S-100beta levels in urine be used as a predictor for the extent of brain damage in head trauma patients? Canadian Journal of Neurological Sciences, 36: 612-616.
Al Ras, A.O. and B.H.J. Juurlink. 2009. Renaming gastrocnemius to biceps tibialis. Clinical Anatomy 22: 637-638.
Davies, G. F., Juurlink, B.H.J. and T.A.A. Harkness. 2009. Troglitazone reverses the multiple drug resistance (MDR) phenotype in cancer. Drug Design, Development and Therapy 3: 79-88
Schültke, E., B.H.J. Juurlink, K. Ataelmannan, J. Laissue, H. Blattmann, E. Bräuer-Krisch, A. Bravin, J. Minczewska, J. Crosbie, H. Taherian, T. Wysokinsky, L.D. Chapman, R. Griebel, D. Fourney. 2008. 2008. Memory and Survival after Microbeam Radiation Therapy. European Journal of Radiology 68 (Suppl 3): 142-146.
Hall, C.J., E. Schültke, L. Rigon, K. Ataelmannan, S. Rigley, R. Menk, F. Arfelli, G. Tromba, S. Pearson, S. Wilkinson, A. Round, S. Crittell, R. Griebel, and B.H.J. Juurlink 2008. Synchrotron based in-vivo tracking of implanted mammalian cells. 2008. European Journal of Radiology 68 (Suppl 3): 156-159.
Senanayake, V., B.H.J. Juurlink, C. Zhang, E. Zhan, L.D. Wilson, J. Kwon, J. Yang, Z.L. Lim, S.M.K. Brunet, G. Schatte, J.M. Maley, R.E. Hoffmeyer and R. Sammynaiken. 2008. Do surface defects and modification determine the observed toxicity of Carbon Nanotubes? Journal of Biomedical Nanotechnology 4: 515-523.
Noyan-Ashraf, M.H., Z. Sadeghinejad, D. Saucier, G.F. Davies, T.A.A. Harkness, A.R. Ross and B.H.J. Juurlink. 2008. Phase 2 protein inducers in the diet promote healthier aging. Journal of Gerontology A: Biological Sciences & Medical Sciences 63: 1168-1176.
Willson, P.J., T. Talaei Khozani, B. H. J. Juurlink, A. Senthilselvan, D. C. Rennie, V. Gerdts, J. Gawaziuk, D. Schneberger, L. H. Burch, J. A. Dosman. 2008. In vitro production of TNF- by human monocytes stimulated with LPS is positively correlated with increased blood monocytes after exposure to a swine barn. Journal of Toxicology and Environmental Health, Part A, 71: 1349-1354.
Kelly, M.E., R.C. Beavis, D. Fiorella, E. Schultke, L.A. Allen, B.H.J. Juurlink, Z. Zhong and L.D. Chapman. 2008. Analyzer-based imaging of spinal fusion in an animal model. Physics in Biology & Medicine 53: 2607-2616.
Kelly, M.E., D.J. Coupal, R.C. Beavis, E. Schültke, K. Romanchuk, B.H.J. Juurlink, Z. Zhong and L.D. Chapman. Diffraction-enhanced imaging of a porcine eye. 2007. Can J. Ophthalmology 42: 731-733.
Kelly, M.E., E. Schultke S. Fiedler, C. Nemoz, R. Guzman, S. Corde, F. Esteve, G. Leduc, B.H.J. Juurlink and K. Meguro, K. 2007. Synchrotron-based intravenous cerebral angiography in a small animal model. Physics in Biology & Medicine 52: 1001-1012.
Wiens, R., M. Rak, N. Cox, S. Abraham, B.H.J. Juurlink, W.M. Kulyk, K. M. Gough. 2007. Synchrotron FITR microspectroscopic analysis of the effects of anti-inflammatory therapeutics on wound healing in laminectomized rats. Analytical & Bioanalytical Chemistry 387: 1679-1689.
Kelly, M.E., R. C. Beavis, D. R. Fourney, E. Schültke, C. Parham, B. H. J. Juurlink, Zhong Zhong, L. D. Chapman. 2006. Diffraction Enhanced Imaging of the Rat Spine. Can. Assoc. Radiol. J. 57: 204-210.
Golding, J.E., S.T. Rigley MacDonald, B.H.J. Juurlink, and B.W.C. Rosser. 2006. The effect of glutamine on locomotory performance and skeletal muscle myosins following acute spinal cord injury in rats. J. Applied Physiol. 101: 1045-1052.
Bambery, KR, E. Schültke, B.R. Wood, S.T. Rigley, K. Ataelmannan, R.W. Griebel, B.H.J. Juurlink and D. McNaughten. 2006. A Fourier transform infrared microspectroscopic imaging investigation into an animal model exhibiting glioblastoma multiforme. Biochim. Biophys. Acta, Biomembranes 1758: 900-907.
Noyan-Ashraf, M.H., L. Wu, R. Wang, B.H.J. Juurlink. 2006. Dietary approaches to positively influence fetal determinants of adult health. FASEB J. 20: 371-373.
Wang, X., K.Desai, B.H.J. Juurlink, J. de Champlain and L. Wu. 2006. Gender-related differences in advanced glycation endproducts, oxidative stress markers and nitric oxide synthases in rats. Kidney International 69: 281-287
Bobyn, J., D. Corbett, D. Saucier, H. Noyan-Ashraf, B.H.J. Juurlink and P.G. Paterson. 2005. Protein-energy malnutrition impairs functional outcome in global ischemia. Exp. Neurol. 196: 308-315.
Schültke, E., H. Kamencic, M. Zhang, G.F. Tian, A.J. Baker, R.W. Griebel and B.H.J. Juurlink. 2005. Neuroprotection following fluid percussion brain trauma: A pilot study using quercetin. J. Neurotrauma 22: 1475-1484
Mannan, K.A., E. Schültke, R.H. Menk, K. Siu, K. Pavlov, M. Kelly, G. McLoughlin, T. Beveridge, G. Tromba, B.H. Juurlink, D. Chapman, L. Rigon and R. Griebel. 2005. Synchrotron supported DEI/KES of a brain tumor in an animal model: The search for a microimaging modality. Nuclear Instruments and Methods in Physics Research A 548: 106-110.
Schültke, E., S. Fiedler, M. Kelly, R. Griebel, B. Juurlink, G. LeDuc, F. Estève, J.-F. Le Bas, M. Renier, C. Nemoz and K. Meguro. 2005. The Potential for Neurovascular Intravenous Angiography using K-Edge Digital Subtraction Angiography. Nuclear Instruments and Methods in Physics Research A 548: 84-87.
Rigley, S., L.Rigon, K.Ataelmannan, D. Chapman, R. Doucette, R.Griebel, B. Juurlink, F. Arfelli, R.-H. Menk, G. Tromba, R.C. Barroso, T. Beveridge, R. Lewis, K. Pavlov, K. Siu, C. Hall and E. Schültke. 2005. Absorption edge subtraction imaging for volumetric measurement in an animal model of malignant brain tumor. Nuclear Instruments and Methods in Physics Research A 548: 88-93.
Davies, G.F., W.J. Roesler, B.H.J. Juurlink and T.A.A. Harkness. 2005. Troglitazone overcomes doxorubicin resistance in resistant K562 leukemia cells. Leukemia and Lymphoma 46: 1199-1206.
Powell, E., G.A. Hill, B.H.J. Juurlink and D.J. Carrier. 2005. Glucoraphanin extraction from Cardaria draba. Part 1: Optimization of batch extraction. J. Chemical Technology & Biotechnology 80: 985-991.
Powell, E., G.A. Hill, B.H.J. Juurlink and D.J. Carrier. 2005. Glucoraphanin extraction from Cardaria draba. Part 2: Countercurrent extraction, bioactivity and toxicity testing. J. Chemical Technology & Biotechnology 80: 992-1007.
Noyan-Ashraf, M.H., Z. Sadeghinejad and B.H.J. Juurlink. 2005. Dietary approach to decrease aging-related CNS inflammation. Nutritional Neuroscience 8: 101-110.
Noyan Ashraf, M.H., F. Brandizzi and B.H.J. Juurlink. 2005. Constitutive nuclear localization of activated caspase 3 in subpopulations of the astroglial family of cells. Glia 49: 588-593.

Book Chapters

Juurlink, B.H.J. 2010. Fumbling towards ecstasy*: A journey to understand a small corner of the universe. Editors: C. Rangacharyulu and Emmanuel Haven, “Proceedings of the First Interdisciplinary CHESS Interactions Conference”, World Scientific Publishing, London, UK, in press.
Goodenowe, D.B., Y. Yamazaki and B.H.J. Juurlink. 2006. Using metabolomics to better understand functional foods. In: S. Iijima and K.-I. Nishijima. Animal Cell Technology: Basic & Applied Aspects. Springer, pp. 21-27.

Teaching:
College of Medicine (Alfaisal University, Riyadh, KSA) (2008 to present)
Undergraduate courses

BIO 211 Human biology and structure (gross anatomy and histology)
PHY 212 Human function (physiology)
GEN 213 Human growths and development (embryology and genetics)
Problem Based Learning (PBL) course, facilitator

University of Saskatchewan(Canada) (1979-2007)
Undergraduate courses:

ANAT 201.3 Developmental Biology
ANAT 202.3 Basic Human Anatomy
ANAT 235.9/233.3 Gross Anatomy, Embryology and Neuroanatomy for Medicine and Dentistry
ANAT 232.6 Cell Biology & Histology for Medicine and Dentistry
ANAT 403.3 Neurobiology
ACB 405.3 Advanced Topics in Cell Biology
ACB 401.6/402.6 Research Project Course and Honor’s Research Project Course

Graduate Courses:

ANAT 898.3 Special Topics: Cellular Neurobiology
ANAT 898.3 Special Topics: Mechanisms of Neurodegeneration
ANAT 898.3 Special Topics: Oxistress & Inflammation
ANAT 813.6 Experimental Medicine
ACB 850.3 Redox, Cell Signalling and Gene Expression
PHARM 858.3 Neuropharmacology

Academic Appointments:

In the Department of Anatomy & Cell Biology, College of Medicine, University of Saskatchewan
1979: Assistant Professor,
1982: Associate Professor
1989: Professor
2000: Professor and Head
In the College of Medicine, University of Saskatchewan
2005-2007 - Acting Associate Dean, Basic Sciences, College of Medicine, University of Saskatchewan
In the College of Medicine, Alfaisal University
2008: Professor of Anatomy and Cell Biology

Honour: Jarislowsky Chair in Biotechnology

Alfaisal University
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