Faculty

Dr. Tianzheng Yu
Associate professor of Physiology
College of Medicine
Alfaisal University

Email: tyu@alfaisal.edu
Tel : +(966-1) 215-7668 office

Education:
M.D.	1994	Hunan Medical University, China
M.S.	1997	Hunan Medical University, China
Postdoctoral	2001-2004	Physiology, Eastern Virginia Medical School, VA, USA
Fellow	2004-2006	Anesthesiology, University of Rochester, NY, USA

Research Interests:

Cell biology of mitochondria – cellular and molecular mechanisms how cells control mitochondrial morphology and distribution, and mitochondrial dynamics in cell life and death;
Mitochondrial diseases – mitochondrial ROS (reactive oxygen species) in cancer, diabetes, cardiovascular diseases and neurodegenerative ;
Renal and cardiovascular physiology – renal and cardiovascular alterations in pregnancy, diabetes and hypertension.

Publications: (Last five years )
Peer-reviewed journal papers:

Yu T, Khraibi AA. Enalapril treatment restores the decreased proximal tubule reabsorption in response to acute volume expansion in diabetic rats. Life Sci. 2008 Aug 29;83(9-10):364-8.
Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res. 2008 Jul 15;79(2):341-51.
Huang P, Yu T, Yoon Y. Mitochondrial clustering induced by overexpression of the mitochondrial fusion protein Mfn2 causes mitochondrial dysfunction and cell death. Eur J Cell Biol. 2007 Jun;86(6):289-302.
Yu T, Khraibi AA. Renal interstitial hydrostatic pressure and natriuretic response to high doses of angiotensin II in pregnant rats. Am J Hypertens. 2006 Mar;19(3):300-5.
Yu T, Robotham JL, Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2653-8.
Khraibi AA, Dobrian AD, Yu T, Solhaug MJ, Billiar RB. Role of RIHP and renal tubular sodium transporters in volume retention of pregnant rats. Am J Hypertens. 2005 Oct;18(10):1375-83.
Yu T, Fox RJ, Burwell LS, Yoon Y. Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. J Cell Sci. 2005 Sep 15;118(Pt 18):4141-51. Epub 2005 Aug 23.
Yu T, Khraibi AA. Natriuretic response to direct renal interstitial volume expansion (DRIVE) in pregnant rats. Am J Hypertens. 2005 Jun;18(6):851-7.

Conference Abstracts:

Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondria 9(1): 72, 2009. Oral presented on Indy 2008: Setting the Pace in Mitochondrial Medicine Scientific Meeting. June 25-28, 2008 in Indianapolis, Indiana.
Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondrial fission participates in overproduction of reactive oxygen species and cell injury in hyperglycemic conditions. Presented on Mitochondrial Biology in Cardiovascular Health & Diseases Conference. October 6 and 7, 2008. National Institutes of Health, Bethesda, Maryland.
Yu T, Yoon Y.. Mitochondrial morphology is an active factor regulating mitochondrial function. Molecular Biology of the Cell 19 (Suppl), 2008. Presented on 48th Annual Meeting of the American Society for Cell Biology, San Francisco, Dec 13-17 2008.
Yu T, Sheu J, Fox RJ, Yoon Y. Identification of signaling components that regulate mitochondrial morphology in high glucose stimulation. Presented on 6th Annual Retreat, Biochemistry, Molecular and Cell Biology (BMCB) Cluster, Casa Larga Vineyards, Fairport, NY, Nov 8, 2007.
Yu T, Sheu J, Fox RJ, Yoon Y. Identification of signaling components that regulate mitochondrial morphology in high glucose stimulation. Molecular Biology of the Cell 18 (S), 2007. Presented on 47th Annual Meeting of the American Society for Cell Biology, Washington DC, Dec 1-5 2007.
Khraibi AA and Yu T. Enalapril Treatment Restores the Attenuated Proximal Tubule Reabsorption in Response to Acute Volume Expansion (VE) in Diabetic Rats. FASEB JOURNAL 20(4): A343-A343 Part 1 MAR 6 2006 (presented at Experimental Biology 2006, April, 2006, San Francisco, CA).
Yu T, Yoon Y, Robotham JL. Increased mitochondrial fission contributes to hyperglycemia-induced acute and prolonged overproduction of reactive oxygen species. Oral presented at Association of University Anesthesiologists 53rd Annual Meeting, Tucson, AZ, May 2006.
Yu T, Fox RJ, Robotham JL, Yoon Y. Mitochondrial dynamics contributes to regulating hepatocytes reactive oxygen species production and cell death in hyperglycemic conditions. Molecular Biology of the Cell 17 (S): 160a-160a, 2006. Presented at 46th Annual Meeting of the American Society for Cell Biology, San Diego, CA, Dec 2006.
Khraibi AA and Yu T. Renal interstitial compliance and natriuresis in pregnant rats. FASEB JOURNAL. 19(4): A576, 2005 (Presented at Experimental Biology 2005, April, 2005, San Diego, CA).
Khraibi AA and Yu T. Natriuretic responses to Angiotensin II (ANG II) in pregnant and nonpregnant rats. FASEB JOURNAL. 19(4): A576-A577, 2005 (Presented at Experimental Biology 2005, April, 2005, San Diego, CA).
Yu T, Fox RJ, Burwell LS, Yoon Y. Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. Oral presented at FEBS-IUBMB Workshop, August, 2005, Padova, Italy.
Yu T, Yoon Y. The mitochondrial outer membrane protein hFis1 regulates mitochondrial fission and apoptosis. Molecular Biology of the Cell 16 (S): 160a-160a, 2005 (Presented to 45th Annual meeting of the American Society for Cell Biology. December, 2005; San Francisco, CA).

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