Faculty

Dr. Moni Nader
Assistant Professor of Physiology
College of Medicine
Alfaisal University
Riyadh, KSA

Email: mnader@alfaisal.edu
Tel: (+966 1) 215- 7674

Education:
Post-Doc	2010	University of Ottawa Heart Institute, Faculty of Medicine, Ottawa, Canada
Ph.D.	2005	University of Sherbrooke, Faculty of Medicine and Health Sciences, Sherbrooke, Canada
B.Sc./M.Sc.	2001	Lebanese University, Faculty of Sciences, Fanar, Lebanon

Honors

2007-2009 Research Fellowship
Heart and Stroke Foundation of Canada, Canada

Research Interest

Structural organization and regulation of the Excitation-Contraction module by scaffold and transmembrane proteins: membrane biology, pathophysiology, and signal transduction in cardiac muscle.
Investigating the role of scaffolding molecules in complex formation and regulation of signaling pathways fundamental for cardiomyocytes function: calcium homeostasis, contraction, cell cycle, proliferation, growth, and death.
Understanding the molecular basis of scaffold proteins in cardiac remodeling (normal and pathological conditions) using animal models with cardiac conditions.

Publications
Refereed journal papers

Bkaily G., Avedanian L., Al-Khoury J., Nader M., D'orleans-Juste P., and Danielle J. (2011) Nuclear membranes receptors for endothelin-1 in cardiovascular function and diseases. Am J Physiol (Accepted), Am J Physiol Regul Integr Comp Physiol 330(2):R251-63.
Avedanian L., Riopel J., Bkaily G., Nader M., D’orleans-Juste P., and Jacques D. (2010) ET-A Receptors are present in Human Vascular Endothelial Cells and modulate intracellular Ca2+. Can J Physiol Pharmacol 88(8):817-29.
Bkaily G., Choufani S., Avedanian L., Ahmarani L., Nader M., Jacques D., D'Orléans-Juste P., and Al-Khoury J. (2008) Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. Can J Physiol Pharmacol. 86(8):546-56.
Pons J., Kitlinska J., Jacques D., Perreault C., Nader M., Everhart L., Zhang Y., and Zukowska Z. (2008) Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth. Can J Physiol Pharmacol. 86(7):438-48.
Cauchon N., Nader M., Bkaily G., Van lier J., and Hunting, D. (2006) Photodynamic Activity of Substituted Zinc Trisulfophthalocyanines: Role of Plasma Membrane Damage. Photochem Photobiol. 82(6):1712-20.
Bkaily G., Nader M., Avedanian L., Choufani S., Jacques, D., D’Orleans-Juste P., Gobeil F., Chemtob S., and Al-Khoury, J. (2006). G-protein coupled receptors, channels and Na+-H+ exchanger in nuclear membranes of heart, hepatic and vascular endothelial and smooth muscle cells. Can. J. Physiol. Pharmacol. 84(3-4):431-41.
Hackett J.A., Hugues A.C., Sarrazin P., Lucena F., Gallant M.A., Fortier I., Nader, M., Parent J.L., Bkaily G., and De Brum-Fernandes. A. J. (2006). Prostaglandin Production by Human Osteoclasts in Culture. J. Rheumatol. 33(7):1320-8.
Gobeil F. Jr, Geha A., Brault S., Zhu T., Vazquez-tello A., Marrache A.M., Checchi D., Hou X., Nader M., Bkaily G., Ribeiro-da-Silva A., Peri K., Bard H., Chorvatova A., Goetzl E.J., and Chemtob, S. (2006). Nitric oxide signaling via nuclearized e-NOS in the expression of immediate early genes I-NOS and MPGES-1. J. Biol. Chem 281(23):16058-67.
Bkaily G., Sculptoreanu A., Wang S., Nader M., Hazzouri K.M., Jacques D., Regoli D., D’Orleans-Juste P. and Avedanian L. (2005). AngiotensinII induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells. Peptides. 26(8): 1410-7.
Bkaily G., El-Bizri N., Nader M., Hazzouri K.M., Jacques D., Regoli D., D’Orleans-Juste P., Gobeil F., and Avedanian, L. (2005). AngiotensinII induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors. Peptides. 26(8): 1418-26.
Chahine M., Bkaily G., Nader M., Al-Khoury J., Jacques D., Beier N. and Scholz W. (2004) NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor. J. Mol. Cell. Cardiol. 38(4): 571-82.
Bkaily G., Nader M., Avedanian L., Jacques D., Perrault C., Abdel-Samad D., D'Orléans-Juste P., Gobeil F., and Hazzouri KM. (2004) Immunofluorescence revealed the presence of NHE-1 in the nuclear membranes of rat cardiomyocytes and isolated nuclei of human, rabbit, and rat aortic and liver tissues. Can J Physiol Pharmacol. 82(8-9):805-11.
Hanna J., Chahine R., Aftimos G., Nader M., Mounayar A., and Esseily, F. (2004). Protective effect of taurine against free radicals damage in the rat myocardium. Exp. Toxicol. Pathol. 56(3):189-94.
Bkaily G., Choufani S., Sader S., Jacques D., D’Orléans-Juste P., Nader M., Kurban G., and Kamal M., (2003). Activation of sarcolemma and nuclear membranes ET-1 receptors regulates transcellular calcium levels in heart and vascular endothelial cells. Can. J. Physiol. Pharmacol. 81(6):654-62.
Bkaily G., Jacques D., D’Orléans-Juste P., Gobeil F., Chemtob S., Choufani S., and Nader M. (2003). Nuclear membranes channels exchangers and G-proteins coupled receptors: a new target for drug action. Current Topics in Pharm. 7(2): 269-278.
Gobeil jr F., Bernier S.G, Vazquez-Tello A., Brault S., Beauchamp M.H., Quiniou C., Marrachje A.-M., Checchin D., Nader M., Bkaily G., Ribeiro-Da-Silva A., Goettzl E.J., and Chemtob S. (2003) Modulation of Pro-Inflammatory Gene Expression Mediated by Nuclear Lysophosphatidic Acid Receptor Type-1. J. Biol. Chem. 278(40):38875-83.

Communications/Abstracts

Nader M., Hawari O., Salih M., Stewart A., Leenen, FHH, and Tuana BS (2010) The tail-anchored membrane protein SLMAP is a novel regulator of E-C coupling and cardiac function. Canadian Cardiovascular Congress, Montreal, Canada.
Nader M., Salih M., Leenen FHH, and Tuana BS (2009) The tail anchored membrane protein SLMAP regulates cell growth by targeting the MAP Kinase pathway and PP2A. American Society for Cell Biology, San Diego, CA, USA.
Nader M., Westendorp B, Salih M, Leenen FHH and Tuana BS (2009) The expression of the sarcolemmal membrane associated protein (SLMAP) is regulated during cardiac remodeling and impacts the MAP Kinase pathway JMCC, Heart Failure 2009 Meeting, Nice, France.
Nader M., Westendorp B, Salih M, Leenen FHH and Tuana BS. (2008) SLMAP overexpression in mouse heart remodels subcellular membranes involved in E-C coupling FASEB J. 22:386.6, Experimental Biology Meeting, San Diego, CA, USA.
Westendorp B, Nader M, Salih M, Leenen FHH and Tuana BS. (2008) Cardiac restricted overexpression of E2F6 alters cell cycle dynamics and results in dilated cardiomyopathy in mice FASEB J. 22:386.8, Experimental Biology Meeting, SanDiego, CA, USA.
Nader M, Westendorp B, Leenen FHH and Tuana BS (2007) Expression of the tail-anchored protein SLMAP in developing myocardium and during remodelling after myocardial infarction FASEB J. 21:969.20 Experimental Biology Meeting, Washington, DC, USA.
Westendorp B, Nader M, Leenen FHH, and Tuana BS (2007) Expression of the cell cycle regulator E2F6 during cardiac development and left ventricular remodeling after myocardial infarction FASEB J. 21:518.3, Experimental Biology Meeting, Washington, DC, USA.
Nader M., Westendorp B., Guzzo R.M., Ahmad M., Leenen F.H.H. and Tuana B.S. (2006) Expression of the tail-anchored protein SLMAP in developing myocardium and during remodelling after myocardial infarction. Canadian Cardiovascular Congress, Vancouver, Canada.
Avedanian L., Nader M., Al-Khoury J., Jacques D. and Bkaily G., (2006) Présence de léchangeur Na+-H+ de type 1 (NHE-1) au niveau des membranes de l’enveloppe nucléaire des cellules du muscle lisse vasculaire et hépathiques humaines. 48ième réunion annuelle du Club de Recherches Cliniques du Québec Lac-à-l’Eau Claire, Canada.

Selected oral presentations

Nader M., Westendorp B, Salih M, Leenen FHH and Tuana BS. (2008) SLMAP overexpression in mouse heart remodels subcellular membranes involved in E-C coupling The FASEB Journal.; 22:386.6 Experimental Biology Meeting, SanDiego, CA, USA.
Nader M., (2005) Believe it or not; G protein coupled receptors are present and functional in the nuclear membranes of different cell types and tissues. Heart Institute, University of Ottawa, Ottawa, ON, Canada.
Nader M., Hanna J., Chahine R. et Rochette L. (2000) Protective effects of taurine against the reperfusion arrhythmias in isolated rat hearts. The national council for scientific research: the Lebanese Association for the Advancement of Science, (14th Science Meeting). American University of Beyrouth, Beyrouth, Lebanon.

Book Chapter

Nader M., Sleiman S., Stephan J., Jacques D., Asselin C., and Bkaily G. (2003) AngiotensinII induced sustained increase of cytosolic and nuclear calcium in aortic vascular smooth muscle cells. Proceedings of the 3rd FEPS Congress Federation of European Physiological Societes. P. Poujeol and O. Peterson Edtrs. Manduzzi Editors-Medimond Inc, Italy. 61-67.

Teaching Experience
College of Medicine, Alfaisal University, Riyadh, KSA

PHY 112 Human Function (Physiology)
PHY 232 Human Function (Physiology)
MOL 113 Molecular Medicine (Cell/Molecular Biology)
Problem Based Learning (PBL) course, facilitator

Faculty of Medicine, University of Ottawa, Ottawa, Canada

Problem Based Learning (PBL) course, facilitator

Alfaisal University
Master Plan Video