Faculty

Dr. Ahmed Yaqinuddin
Assistant Professor of Anatomy & Cell biology
College of Medicine
Alfaisal University
Riyadh, KSA

Email:
Tel : +(966-1) 215-7652 office

Education:
PhD (Anatomy)	2008	Aga Khan University, Karachi, Pakistan
MBBS	1996	Baqai Medical college, University of Karachi, Pakistan

Professional Training/ Positions:
Assistant Professor	2009-present	Aga Khan University, Karachi, Pakistan.
Instructor (Anatomy)	2006-2008	Aga Khan University, Karachi, Pakistan.
Doctoral Fellow	2002-2008	Aga khan University, Karachi, Pakistan.
Instructor (Anatomy)	2000-2002	Shifa College of Medicine, Islamabad, Pakistan.
Instructor (Anatomy)	1998-2000	Islamabad Medical College, Islamabad, Pakistan.
Senior House Surgeon	1997-1998	Surgical Rotations in University and Central Hospital – Riyadh

Research Interests:

Role of epigenetic mechanisms in development and progression of cancers
Utility of epigenetic markers ( DNA methylation and miRNAs) to detect and prognosticate cancers

Current projects:

Using microRNAs as a biomarker to diagnose and prognosticate breast cancer
Global methylation profiling in bladder cancer; An approach to discover novel diagnostic and prognostic biomarkers
A novel approach to non invasive prenatal diagnosis feotal Rhesus-D status by isolating cell free feotal DNA in maternal Plasma

Publications: (Last five years )
Refereed journal papers:

Yaqinuddin A, Abbas F, Naqvi Z, Bashir MU, Qazi R, Qureshi SA, “Silencing of MBD1 and MeCP2 in prostate cancer derived PC3 cells produces differential gene expression profiles and cellular phenotypes” Bioscience Reports 28 (6):319-326 2008.
Yaqinuddin A, Abbas F, Qazi R, Qureshi SA “Down regulation of DNMT3b in PC3 cells, effects locus specific DNA methylation and represses cellular growth and migration” Cancer Cell International 2008, 8:13
Yaqinuddin A, Abbas F, farooq S, Qazi R, Qureshi SA “DNMT1 silencing effects locus specific DNA methylation and increases Invasiveness of Prostate Cancer Derived PC3 cells. Journal of Urology 2008 (In Press)
Kakal F, Yaqinuddin A, Somani M, Mohammed N” Frequent hypermethylation of APC, RAR- and RASSF1A in human term placentas” Placenta (accepted)
Yaqinuddin A, Bashir MU” Role of DNA Methylation markers in diagnosis of Cancer” Journal of college of Physicians and Surgeons Pakistan 2008 (submitted)

Published Abstracts:

Yaqinuddin A, Abbas F, Qureshi SA, “Distinct role of DNA methyltransferases and methyl-CpG binding proteins on apoptosis, invasion, proliferation and migration of Prostate cancer cell-an invitro study” Urology 2007;70 (Supplement 3A) 134
Mohammed N, Yaqinuddin A, Waheed M “RASSF1A, APC, RAR-Beta Tumor suppressor genes hypermethylation in normal term placentas: implications for pathophysiology of preeclampsia J Perinat Med 2007 Suppl II S 80

Conference Abstracts:

Mohammed N, Yaqinuddin A, Kakal F, Qureshi R, Sheikh L “Introduction of uterine artery doppler screening program in the second trimester for prediction of preeclampsia in Pakistan” invited for oral talk at the 8th International Congress of IDSSG, Vancouver, Canada (2008)
Mohammed N, Kakal F, Yaqinuddin A, Somani M, Sheikh L, Qureshi R “Hypermethylation of APC and RASSF1A tumour suppressor genes in normal placentas at term using Real-Time PCR: potential predictive marker of Preeclampsia?” abstract and poster presented at The 16th World Congress of International Society for the Study of Hypertension in Pregnancy (ISSHP), Washington DC, USA (2008)
Mohammed N, Kakal F, Yaqinuddin A, Somani M, Khan Y, Sheikh L, Qureshi, R “Quantification of cell-free fetal DNA from maternal plasma: Implications for non-invasive prenatal diagnosis of genetic disorders in Pakistan” abstract and poster presented at International Congress of Fetal Medicine, Warsaw, Poland (2008)
Siddiqui N, Naqvi Z, Mushtaq S, Yaqinuddin A, Siddiqui A “Proteomic Response of epithelial cells to mechanical abrasion” abstract and poster presented at HUPO, Seoul, Korea (2007)
Yaqinuddin A, Abbas F, Qureshi SA ”Effects of demethylation on Proliferation, migration, Invasion of metastatic Prostate Cancer” abstract and poster presented at Faculty Research Assembly AKU, Karachi, Pakistan (2007)
Yaqinuddin A, Abbas F, Qureshi SA, Qazi R, “Effects of blocking DNA methylation on invasiveness of Prostate cancer cell lines” abstract and poster presented at Faculty Research Assembly AKU, Karachi, Pakistan (2006)
Yaqinuddin A, Abbas F, Qureshi SA, “Prostate cancer: Role of molecular markers in diagnosis and prognosis” abstract and poster presented at Faculty Research Assembly AKU, Karachi, Pakitan (2005)

Workshops facilitated:

“Fundamentals of Tissue Engineering” Aug 28-30, 2008 at Juma Research Laboratory, Aga Khan University, Karachi, Pakistan.
“Invivo and invitro assays for study of pain mechanisms” Sep 7-9, 2006 at Juma Research Laboratory, Aga Khan University, Karachi, Pakistan.
“Genetic and biochemical aspects of inheritable metabolic disorders” 2005 at Juma Research Laboratory, Aga Khan University, Karachi, Pakistan.
“Molecular and Analytical Techniques in research and diagnosis of reproductive disorders” 2004 at Juma Research Laboratory, Aga Khan University, Karachi, Pakistan.

Teaching:

Teaching Anatomy through lectures, tutorials, lab sessions to Undergraduate medical students, Islamabad Medical and Dental College, Islamabad 1998-2000.
Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students, Shifa College of Medicine, Islamabad, 2000-2002.
Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students Aga Khan University, Karachi 2002- to-date.
Working as Point Person Anatomy with responsibility to manage overall teaching related activities of Anatomy discipline in the Department of Biological and Biomedical Sciences, the Aga Khan University, Karachi 2008-todate.
Co-Chair Year I Curriculum Sub-Committee, Medical College, Aga Khan University, 2009-todate
Co-Chair Head &Neck and Special Senses Module, Medical College, Aga Khan University, 2008-to-date
Member, Year II Curriculum Sub-Committee, Medical College, Aga Khan University, 2008-to-date

Alfaisal University
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